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At an evening function Adams gave the following toast: "Baltimore: the Monumental City—May the days of her safety be as prosperous and happy, as the days of her dangers have been trying and triumphant." Baltimore pioneered the use of gas lighting in 1816 and its population grew rapidly in the following decades, with concomitant development of culture and infrastructure.The construction of the federally funded National Road (which later became part of U. Route 40) and the private Baltimore and Ohio Railroad (B.The Town of Baltimore, on the west side of the Jones Falls, was founded and laid out on July 30, 1729; with Jonestown and Fells Point preexisting to the east.The three settlements, covering 60 acres, became a commercial hub and in 1768 became the county seat.A total of 11,000 Maryland National Guard and federal troops were ordered into the city.Following the death of Freddie Gray in April 2015, the city experienced major protests and international media attention, as well as a clash between local youth and police which resulted in a state of emergency declaration and curfew.
and is home to some of the earliest National Register Historic Districts in the nation, including Fell's Point, Federal Hill, and Mount Vernon, which were added to the National Register between 1969–1971. The city has 66 National Register Historic Districts and 33 local historic districts. The Baltimore area had been inhabited by Native Americans since at least the 10th millennium BC, when Paleo-Indians first settled in the region.
After a decline in major manufacturing, industrialization, and rail transportation, Baltimore shifted to a service-oriented economy, with Johns Hopkins Hospital (founded 1889) and Johns Hopkins University (founded 1876), now the city's top two employers.